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| Nomenclature |
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Symbol:
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Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
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Name:
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transgene insertion VF1-07, Maria Eriksson
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MGI ID: |
MGI:3834666 |
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Synonyms: |
tetop-LAG608G |
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Transgene:
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Tg(tetO-LMNA*G608G,-EGFP)VF1-07Maer
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human gene from a patient with Hutchinson-Gilford progeria syndrome, in which a nucleotide substitution (1824C>T; G608G) activates a cryptic splice site, was inserted downstream of a tetracycline promoter and upstream of an IRES-EGFP. Eight lines were created. (J:145312)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:145312
Sagelius H et al.,
"Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease."
J Cell Sci 2008 Apr 1;121(Pt 7):969-78
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All: |
2 reference(s)
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Analysis Tools
