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| Nomenclature |
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Symbol:
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Tg(ATN1*)Q129Stsu
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Name:
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transgene insertion Q129, Shoji Tsuji
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MGI ID: |
MGI:3834570 |
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Synonyms: |
Q129 |
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Transgene:
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Tg(ATN1*)Q129Stsu
Location:
unknown
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Transgene
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144379
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Parent Cell Line:
| CCE/EK.CCE (ES Cell) |
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Strain of Origin:
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129S/SvEv-Gpi1c
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene was engineered from BAC DRPLA18E that contains the human gene for ATN1 from a patient with dentatorubral-pallidoluysian atrophy (DRPLA) with a 76 CAG trinucleotide repeat within the gene. During maintenance of Tg(ATN1*)Drm21Stsu a mosaic mouse was isolated contained a combination of cells with 76 CAG repeats and 129 CAG repeats within the transgene. This mouse was bred to produce a line with the mutant human ATN1 with 129 CAG repeats. (J:144379)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:144379
Sato T et al.,
"Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice."
Hum Mol Genet 2009 Feb 15;18(4):723-36
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All: |
1 reference(s)
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Analysis Tools
