Mapping and Phenotype information for this QTL, its variants and associated markers
Genetic loci affecting mandible size and shape were mapped using 190 mice from a (C57BL/6JJcl x KK-A<y>/TaJcl)F2 intercross. Of the F2 population, 97 animals had the A<y>/a genotype and 93 animals had the a/a genotype. Thirteen measurements taken from the right mandible and 3 principal components were assessed in experimental animals 6-7 months of age. Parental strain KK-A<y>/TaJcl displays increased values across most of the 13 mandible measurements compared to parental strain C57BL/6JJcl. The A<y> allele increases mandible size in KK animals compared to the a allele. A panel of 100 polymorphic markers was used for linkage analysis.
Mssq9 (mandible size and shape QTL 9) mapped to 61 cM on mouse Chromosome 9 near D9Mit212 in the combined F2 population.C57BL/6JJcl-derived alleles at Mssq9 confer increased mandible size for two mandible measurements. Mssq9 also displays suggestive linkage to mandible size in the a/a F2 group (LOD=2.3) and the A<y>/a F2 group (LOD=2.6).