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| Nomenclature |
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Symbol:
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Tg(Thy1-MAPT*V337M)1Godt
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Name:
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transgene insertion 1, Michel Goedert
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MGI ID: |
MGI:3832877 |
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Synonyms: |
TauV337M, Tg(Thy1-MAPT*V337M)1Migo |
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Transgene:
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Tg(Thy1-MAPT*V337M)1Godt
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x CBA/Ca)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The promoter was used to drive brain-specific expression of a cDNA that encodes the longest three-repeat human isoform with nucleotide substitutions resulting in the amino acid substitution of methionine for valine at position 337 (V337M). This mutation was originally identified in patients with frontotemporal dementias with Parkinsonism linked to chromosome 17 (FTDP-17). No line information was given.
(J:143018)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:143018
Lambourne SL et al.,
"Impairments in impulse control in mice transgenic for the human FTDP-17 tauV337M mutation are exacerbated by age."
Hum Mol Genet 2007 Jul 15;16(14):1708-19
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All: |
1 reference(s)
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Analysis Tools
