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| Nomenclature |
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Symbol:
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Pot1btm1.1Schg
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Name:
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protection of telomeres 1B;
targeted mutation 1.1, Sandy Chang
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MGI ID: |
MGI:3831881 |
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Gene:
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Pot1b
Location:
Chr17:55652025-55712628 bp, - strand
Genetic Position: Chr17,
28.93 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144553
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Cre mediated recombination of Pot1btm1Schg removed exons 3 and 4. RT-PCR confirmed the absence of mRNA transcripts in homozygous MEFs. (J:144553)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Pot1b Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:144553
He H et al.,
"Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita."
Mol Cell Biol 2009 Jan;29(1):229-40
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All: |
2 reference(s)
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Analysis Tools
