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| Nomenclature |
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Symbol:
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Nfatc1tm3Glm
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Name:
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nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1;
targeted mutation 3, Laurie H Glimcher
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MGI ID: |
MGI:3831720 |
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Synonyms: |
Nfatc1fl |
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Gene:
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Nfatc1
Location:
Chr18:80606205-80713071 bp, - strand
Genetic Position: Chr18,
53.66 cM, cytoband E4
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144598
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP site replaced 3 kb of intronic sequence upstream of exon 3 and a floxed neomycin cassette replaced was placed downstream of the exon into a XbaI site. Mice derived from correctly targeted ES cells were crossed with EIIa-cre transgenic mice and progeny were selected by Southern blotting for selective loss of the neomycin resistance cassette. Protein expression was unaffected as determined by immunoblotting of splenocyte extracts. Cre-mediated excision of exon 3 will remove a regulatory domain necessary for proper protein function. (J:144598)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nfatc1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:144598
Aliprantis AO et al.,
"NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism."
J Clin Invest 2008 Nov;118(11):3775-89
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All: |
8 reference(s)
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Analysis Tools
