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| Nomenclature |
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Symbol:
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Id1tm1Xhsu
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Name:
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inhibitor of DNA binding 1;
targeted mutation 1, Xiao-Hong Sun
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MGI ID: |
MGI:3831561 |
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Synonyms: |
Id1GFP |
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Gene:
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Id1
Location:
Chr2:152736251-152737410 bp, + strand
Genetic Position: Chr2,
75.41 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144696
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: An eGFP vector and a floxed neomycin cassette was knocked into the untranslated region of exon 1 of the gene locus. Founder mice were crossed with EIIa-cre transgenic mice to remove the neomycin cassette, leaving behind a loxP site. GFP expression was detected in bone marrow cells of myeloid lineages in both heterozygote and homozygote mice. Endogenous protein was not detected in immunobloting of cytokine-stimulated bone marrow cells from homozygote mice confirming this is a null allele. (J:144696)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:144696
Perry SS et al.,
"Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance."
Blood 2007 Oct 1;110(7):2351-60
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All: |
4 reference(s)
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Analysis Tools
