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| Nomenclature |
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Symbol:
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Fgfr3tm1.1Aomw
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Name:
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fibroblast growth factor receptor 3;
targeted mutation 1.1, Andrew O M Wilkie
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MGI ID: |
MGI:3831364 |
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Synonyms: |
Fgfr3P244R |
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Gene:
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Fgfr3
Location:
Chr5:33721724-33737067 bp, + strand
Genetic Position: Chr5,
17.83 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144356
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A point mutation changing a C to G at position 731 in exon 7 and a floxed neo cassette in intron 7 were introduced by homologous recombination. The neo cassette was then removed by Cre mediated recombination. (J:144356)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:144356
Twigg SR et al.,
"Skeletal analysis of the Fgfr3(P244R) mouse, a genetic model for the Muenke craniosynostosis syndrome."
Dev Dyn 2009 Feb;238(2):331-42
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All: |
3 reference(s)
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Analysis Tools
