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| Nomenclature |
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Symbol:
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Tg(Pbsn-IGF1*)5305Ng
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Name:
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transgene insertion 5305, Norman M Greenberg
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MGI ID: |
MGI:3831172 |
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Synonyms: |
IGF-1des, PB-Des, PB Des IGF-1, PB-IGF1des1,3 |
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Transgene:
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Tg(Pbsn-IGF1*)5305Ng
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing the human insulin-like growth factor 1 (somatomedin C) isoform, IGF-1des (that has a 3-amino acid deletion in the N terminus of the mature protein), under the control of the minimal -426/+28 rat probasin promoter, and carrying SV40 polyadenylation site sequences was injected into fertilized FVB/N mouse eggs. Three lines were generated (5299, 5305, and 6206). Founder line 5305 showed the highest expression and was characterized most thoroughly. (J:144539)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:144539
Kaplan-Lefko PJ et al.,
"Enforced epithelial expression of IGF-1 causes hyperplastic prostate growth while negative selection is requisite for spontaneous metastogenesis."
Oncogene 2008 May 1;27(20):2868-76
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All: |
1 reference(s)
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Analysis Tools
