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| Nomenclature |
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Symbol:
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Foxa1tm1Khk
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Name:
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forkhead box A1;
targeted mutation 1, Klaus H Kaestner
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MGI ID: |
MGI:3831160 |
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Synonyms: |
Foxa1flox, Foxa1loxP |
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Gene:
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Foxa1
Location:
Chr12:57540631-57546121 bp, - strand
Genetic Position: Chr12,
24.7 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:143476
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 2, and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed. (J:143476)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxa1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:143476
Gao N et al.,
"Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development."
Genes Dev 2008 Dec 15;22(24):3435-48
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All: |
8 reference(s)
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Analysis Tools
