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| Nomenclature |
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Symbol:
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Traf3ip2tm1Sbn
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Name:
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TRAF3 interacting protein 2;
targeted mutation 1, Ulrich Siebenlist
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MGI ID: |
MGI:3831153 |
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Synonyms: |
CIKS- |
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Gene:
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Traf3ip2
Location:
Chr10:39612934-39655307 bp, + strand
Genetic Position: Chr10,
20.86 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144320
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3.6 Kb BamHI fragment containing exon 2 was replaced with a neomycin selection cassette. Correct targeting was confirmed by Southern blotting. Analysis of mRNAs from homozygote B cells demonstrates exon 1 was spliced to exon 3. All potential ATG start codons upstream of exon 3 and located in the correct reading frame are followed by at least 2 stop codons prior to the start of exon 3. The first ATG present within the functional reading frame downstream of the start of exon 3 is located in exon 5, which could only generate a 157 amino acid long fragment of the 555 amino acid endogenous protein. For these reasons, a functional protein product was considered unlikely. (J:144320)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Traf3ip2 Mutation:
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20 strains or lines available |
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| References |
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Original: |
J:144320
Claudio E et al.,
"The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation."
J Immunol 2009 Feb 1;182(3):1617-30
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All: |
3 reference(s)
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Analysis Tools
