Tg(Neurod2-Smo*A1)199Jols
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Neurod2-Smo*A1)199Jols
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Name:
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transgene insertion 199, James M Olson
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MGI ID: |
MGI:3830738 |
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Synonyms: |
ND2:SmoA1, SmoA1, SmoA1:199 |
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Transgene:
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Tg(Neurod2-Smo*A1)199Jols
Location:
unknown
Genetic Position: Chr14,
cytoband C1
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The ND2:SmoA1 transgene contains the entire mouse smoothened homolog (Drosophila) Smo gene, with the constitutively active point mutation SmoA1 (W539L), driven by the 1kb mouse neurogenic differentiation 2 (Neurod2) promoter. Several lines were generated (lines 199, 193, 234, 255 and 201) with varying levels of expression (30-, 45-, 36-, 2- and 3-fold, respectively, relative to wild0type expression). (J:93861)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:93861
Hallahan AR et al.,
"The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas."
Cancer Res 2004 Nov 1;64(21):7794-800
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All: |
14 reference(s)
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Analysis Tools
