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| Nomenclature |
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Symbol:
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Ptrftm1Pfp
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Name:
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polymerase I and transcript release factor;
targeted mutation 1, Paul F Pilch
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MGI ID: |
MGI:3829005 |
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Synonyms: |
Cavin- |
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Gene:
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Ptrf
Location:
Chr11:100956733-100970887 bp, - strand
Genetic Position: Chr11,
63.95 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:143425
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 1 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on lung and adipocyte extracts. (J:143425)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:143425
Liu L et al.,
"Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance."
Cell Metab 2008 Oct;8(4):310-7
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All: |
3 reference(s)
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Analysis Tools
