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| Nomenclature |
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Symbol:
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Tg(Dspp-TGFB1)3Kul
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Name:
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transgene insertion 3, Ashok B Kulkarni
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MGI ID: |
MGI:3828146 |
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Synonyms: |
dTGF-beta1, Tg(TGFB1)3Kul |
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Transgene:
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Tg(Dspp-TGFB1)3Kul
Location:
unknown
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Gross tooth abnormalities in Tg(Dspp-TGFB1)3Kul/? mice
Show the 3 image(s) involving this allele.
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene comprises 6 kilobases of mouse genomic DNA containing the upstream regulatory elements of the dentin sialophosphoprotein (Dspp) gene, including the noncoding first exon and the first intron, followed by a 1.5 kb cDNA encoding a constitutively active porcine transforming growth factor beta 1, in which Cys223 and Cys225 have been replaced by serine, and an SV40 polyadenylation signal. Transgenic mouse lines with independent transgene integration sites were produced from 5 transgenic founder animals. This record represents the line of mice with a high level of transgene expression. TGFB1 is expressed from this transgene predominantly in the odontoblasts. (J:118918)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:118918
Thyagarajan T et al.,
"Reduced expression of dentin sialophosphoprotein is associated with dysplastic dentin in mice overexpressing transforming growth factor-beta 1 in teeth."
J Biol Chem 2001 Apr 6;276(14):11016-20
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All: |
3 reference(s)
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Analysis Tools
