|
|
| Nomenclature |
|
Symbol:
|
Rhohtm1Brak
|
|
Name:
|
ras homolog gene family, member H;
targeted mutation 1, Cord Brakebusch
|
|
MGI ID: |
MGI:3826431 |
|
Synonyms: |
RhoH- |
|
Gene:
|
Rhoh
Location:
Chr5:65863569-65896700 bp, + strand
Genetic Position: Chr5,
33.8 cM, cytoband D
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:143161
|
|
Parent Cell Line:
| Not Specified (ES Cell) |
|
Strain of Origin:
|
Not Specified
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: A 0.9 kb fragment encoding the first 42 amino acids was replaced with a neomycin resistance cassette. This removes the translation start site and the switch 1 region. Northern blot analysis indicated that no normal protein was expressed. (J:143161)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Rhoh Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:143161
Dorn T et al.,
"RhoH is important for positive thymocyte selection and T-cell receptor signaling."
Blood 2007 Mar 15;109(6):2346-55
|
|
All: |
4 reference(s)
|
|
Analysis Tools
