|
|
| Nomenclature |
|
Symbol:
|
Ezh2tm2.1Sho
|
|
Name:
|
enhancer of zeste homolog 2 (Drosophila);
targeted mutation 2.1 Stuart Orkin
|
|
MGI ID: |
MGI:3823218 |
|
Synonyms: |
Ezh2- |
|
Gene:
|
Ezh2
Location:
Chr6:47530274-47595341 bp, - strand
Genetic Position: Chr6,
22.92 cM, cytoband B
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:142193
|
|
Parent Cell Line:
| CJ7 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-out) |
|
Mutations: | |
Insertion, Intragenic deletion |
| |
|
Mutation details: Germ line, cre mediated recombination was used to remove exons 14 and 15. The absence of protein expression was confirmed by western blot analysis on embryonic stem cells. (J:142193)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Ezh2 Mutation:
|
25 strains or lines available |
|
| References |
|
Original: |
J:142193
Shen X et al.,
"EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency."
Mol Cell 2008 Nov 21;32(4):491-502
|
|
All: |
3 reference(s)
|
|
Analysis Tools
