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| Nomenclature |
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Symbol:
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Ezh2tm2Sho
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Name:
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enhancer of zeste homolog 2 (Drosophila);
targeted mutation 2, Stuart Orkin
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MGI ID: |
MGI:3823217 |
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Synonyms: |
Ezh2fl |
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Gene:
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Ezh2
Location:
Chr6:47530274-47595341 bp, - strand
Genetic Position: Chr6,
22.92 cM, cytoband B
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:142193
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo cassette was inserted into intron 13 and an additional loxP site was inserted into intron 15. Transient cre expression was used to remove the neo cassette in ES cells leaving exons 13 and 14 floxed. (J:142193)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ezh2 Mutation:
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25 strains or lines available |
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| References |
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Original: |
J:142193
Shen X et al.,
"EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency."
Mol Cell 2008 Nov 21;32(4):491-502
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All: |
4 reference(s)
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Analysis Tools
