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| Nomenclature |
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Symbol:
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Tg(RNU6-RNAi:Cldn16)551Dago
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Name:
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transgene insertion 551, Daniel A Goodenough
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MGI ID: |
MGI:3822350 |
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Synonyms: |
pUG-U6-551, Tg(UBC-RNAi:Cldn16)551Dago |
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Transgene:
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Tg(RNU6-RNAi:Cldn16)551Dago
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human promoter was used to drive ubiquitous expression of GFP and a short hairpin RNA targeting Cldn16. Three lines were created (lines 453, 551 and 756) with line 756 exhibiting no knockdown effect with the other two lines down regulating transcript expression by greater than 100-fold as determined by real time quantitative RT-PCR. (J:122766)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:122766
Hou J et al.,
"Transgenic RNAi depletion of claudin-16 and the renal handling of magnesium."
J Biol Chem 2007 Jun 8;282(23):17114-22
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All: |
3 reference(s)
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Analysis Tools
