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| Nomenclature |
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Symbol:
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Tg(Myh7-Ptpn11*Q79R)11Rbns
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Name:
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transgene insertion 11, Jeffrey Robbins
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MGI ID: |
MGI:3822132 |
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Synonyms: |
beta-MHC-Q97R11 |
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Transgene:
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Tg(Myh7-Ptpn11*Q79R)11Rbns
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The promoter was used to drive expression of Ptpn11 containing the amino acid substitution of arginine for glutamine at position 79 in the fetal heart. This mutation results in an increase in phosphatase activity. Several lines were created and line 11 was used in subsequent experiments. Line 14 expresses the transgene at lower levels than line 11.
(J:123963)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:123963
Nakamura T et al.,
"Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome."
J Clin Invest 2007 Aug;117(8):2123-32
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All: |
1 reference(s)
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Analysis Tools
