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| Nomenclature |
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Symbol:
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Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
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Name:
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transgene insertion 1, Jeffrey Robbins
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MGI ID: |
MGI:3822129 |
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Synonyms: |
CAGCAT-Q79R-Shp2 |
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Transgene:
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Tg(CAG-cat,-Ptpn11*Q97R)1Rbns
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The ubiquitous CAG (chicken beta actin) promoter was used to drive cre-dependent expression of a modified Ptpn11 gene, which contains the amino acid substitution of arginine for glutamine at position 79, following removal of an intervening floxed chloramphenicol (cat) gene. The amino acid substitution results in an increase in phosphatase activity. Three lines were created and line 1 was used in subsequent experiments. (J:142212)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:142212
Krenz M et al.,
"Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome."
Proc Natl Acad Sci U S A 2008 Dec 2;105(48):18930-5
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All: |
2 reference(s)
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Analysis Tools
