Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis
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Name:
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transgene insertion 35-1, Yuji Mishina
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MGI ID: |
MGI:3821884 |
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Synonyms: |
CAG-Z-EGFP-caAlk2 |
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Transgene:
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Tg(CAG-LacZ,-ACVR1*,-EGFP)35-1Mis
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The modified chicken beta-actin promoter (CAG) was used to drive ubiquitous expression of a floxed LacZ gene with a triple polyadenylation sequence followed by a constitutively active human ACVR1 sequence with the amino acid substitution of aspartic acid for glutamine at position 207 (Q207D), an IRES sequence, and the EGFP coding sequence. Five lines were established and expression analysis for one line (line 35-1) confirmed general, but not ubiquitous, expression of LacZ and cre-dependent general expression of the modified ACVR1 and EGFP. (J:109498)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:109498
Fukuda T et al.,
"Generation of a mouse with conditionally activated signaling through the BMP receptor, ALK2."
Genesis 2006 Apr;44(4):159-67
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All: |
3 reference(s)
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Analysis Tools
