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| Nomenclature |
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Symbol:
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Zbtb7btm1.2Litt
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Name:
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zinc finger and BTB domain containing 7B;
targeted mutation 1.2, Dan R Littman
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MGI ID: |
MGI:3821621 |
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Synonyms: |
ThPOK- |
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Gene:
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Zbtb7b
Location:
Chr3:89377644-89394776 bp, - strand
Genetic Position: Chr3,
39.09 cM, cytoband A1-A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141144
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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B6(Cg)-Tyrc-2J/J
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Mice carrying the Zbtb7btm1Litt allele were crossed with a cre transgenic strain to remove the entire coding sequence of the gene locus from germline cells, leaving behind a single loxP site. No protein expression was detected in immunoblot analysis of thymocytes. (J:141144)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:141144
Egawa T et al.,
"ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage."
Nat Immunol 2008 Oct;9(10):1131-9
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All: |
1 reference(s)
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Analysis Tools
