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| Nomenclature |
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Symbol:
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Zbtb7btm1Litt
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Name:
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zinc finger and BTB domain containing 7B;
targeted mutation 1, Dan R Littman
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MGI ID: |
MGI:3821617 |
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Synonyms: |
ThPOKFN |
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Gene:
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Zbtb7b
Location:
Chr3:89377644-89394776 bp, - strand
Genetic Position: Chr3,
39.09 cM, cytoband A1-A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141144
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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B6(Cg)-Tyrc-2J/J
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The coding sequence of this gene locus is contained within exons 2 and 3. A loxP-flanked neomycin resistance cassette was placed upstream of exon 2 and an additional loxP site was placed downstream of exon 3. The presence of the neomycin resistance cassette created a hypomorph allele where protein expression was reduced by 80% in CD4+ T cells from mice compound heterozygote for this allele and a null allele. (J:141144)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Zbtb7b Mutation:
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14 strains or lines available |
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| References |
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Original: |
J:141144
Egawa T et al.,
"ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage."
Nat Immunol 2008 Oct;9(10):1131-9
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All: |
1 reference(s)
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Analysis Tools
