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| Nomenclature |
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Symbol:
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Hbb-b1MommeD7
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Name:
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hemoglobin, beta adult major chain;
modifier of murine metastable epialleles, D7
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MGI ID: |
MGI:3821597 |
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Synonyms: |
RBC14 |
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Gene:
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Hbb-b1
Location:
unknown
Genetic Position: Chr7,
54.85 cM
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Mutation
origin |
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: ENU induced a T to C substitution at position 757 in the mRNA altering the canonical polyadenylation signal. Northern blot analysis on RNA from fetal liver cells from homozygous and heterozygous mice detected reduced expression of the wild-type transcript and the presence of larger RNA species not seen in wild-type samples. (J:190446)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hbb-b1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:142335
Ashe A et al.,
"A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development."
Genome Biol 2008 Dec 19;9(12):R182
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All: |
2 reference(s)
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Analysis Tools
