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| Nomenclature |
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Symbol:
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Telo2tm1.1Tdl
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Name:
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TEL2, telomere maintenance 2, homolog (S. cerevisiae);
targeted mutation 1.1, Titia de Lange
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MGI ID: |
MGI:3819391 |
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Synonyms: |
Tel2DEL |
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Gene:
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Telo2
Location:
Chr17:25099570-25115967 bp, - strand
Genetic Position: Chr17,
12.53 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141633
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Transient cre expression in ES cells was used to remove the floxed exon 3 and the neo cassette. This deletion results in a frame shift and premature termination of translation at amino acid 168 of 840. A two-fold reduction in protein expression levels was confirmed by western blot analysis on embryonic fibroblasts heterozygous for the allele. (J:141633)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Telo2 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:141633
Takai H et al.,
"Tel2 regulates the stability of PI3K-related protein kinases."
Cell 2007 Dec 28;131(7):1248-59
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All: |
1 reference(s)
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Analysis Tools
