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| Nomenclature |
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Symbol:
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Txniptm1Rlee
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Name:
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thioredoxin interacting protein;
targeted mutation 1, Richard T Lee
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MGI ID: |
MGI:3818743 |
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Synonyms: |
Txnipflox |
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Gene:
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Txnip
Location:
Chr3:96557957-96561883 bp, + strand
Genetic Position: Chr3,
41.93 cM, cytoband F2.2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141487
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted 168 bp upstream of the first ATG codon in exon 1 and an frt flanked neo cassette and second loxP were inserted downstream of exon 1 via homologous recombination. The neo cassette was removed via in vivo Cre-mediated recombination.(J:141487)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:141487
Yoshioka J et al.,
"Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload."
Circ Res 2007 Dec 7;101(12):1328-38
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All: |
3 reference(s)
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Analysis Tools
