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| Nomenclature |
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Symbol:
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Hgstm2Tkh
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Name:
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HGF-regulated tyrosine kinase substrate;
targeted mutation 2, Nobuyuki Tanaka
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MGI ID: |
MGI:3818694 |
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Synonyms: |
hrsloxP |
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Gene:
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Hgs
Location:
Chr11:120467635-120483979 bp, + strand
Genetic Position: Chr11,
84.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:141391
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 2 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exons 2 through 4 floxed. (J:141391)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hgs Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:141391
Tamai K et al.,
"Loss of hrs in the central nervous system causes accumulation of ubiquitinated proteins and neurodegeneration."
Am J Pathol 2008 Dec;173(6):1806-17
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All: |
2 reference(s)
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Analysis Tools
