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| Nomenclature |
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Symbol:
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Leprm3Btlr
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Name:
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leptin receptor;
mutation 3, Bruce Beutler
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MGI ID: |
MGI:3817472 |
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Synonyms: |
well-upholstered |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: This mutation, identified by its phenotype among G3 progeny of an ENU mutagenized male mouse, is a G to A transition at nucleotide position 2421 (variant 1; Genbank accession NM_146146), in the 12th of the gene's 18 exons. It results in the replacement of a tryptophan codon at amino acid position 623 by a stop codon (W623Ter), which truncates the receptor by 539 amino acids at its C terminus. (J:140985)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lepr Mutation:
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27 strains or lines available |
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| References |
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Original: |
J:140985
Siggs OM et al.,
"Record for "well-upholstered", updated November 13, 2008"
MGI Direct Data Submission 2008;():
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All: |
1 reference(s)
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Analysis Tools
