|
|
| Nomenclature |
|
Symbol:
|
Six3tm3Gco
|
|
Name:
|
sine oculis-related homeobox 3;
targeted mutation 3, Guillermo Oliver
|
|
MGI ID: |
MGI:3814869 |
|
Synonyms: |
Six3cki, Six3V250 |
|
Gene:
|
Six3
Location:
Chr17:85613608-85631813 bp, + strand
Genetic Position: Chr17,
55.42 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:140315
|
|
Parent Cell Line:
| W9.5/W95 (ES Cell) |
|
Strain of Origin:
|
129S1/Sv-Oca2+ Tyr+ Kitl+
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A single bp transition (T749C) was introduced into the first exon. This causes a valine to alanine change at amino acid residue 250. In addition, a floxed cassette containing a stop codon and a neomycin resistance gene was inserted upstream of the first exon thus inactivating the knocked-in mutation. (J:140315)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Six3 Mutation:
|
1 strain or line available |
|
| References |
|
Original: |
J:140315
Geng X et al.,
"Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly."
Dev Cell 2008 Aug;15(2):236-47
|
|
All: |
1 reference(s)
|
|
Analysis Tools
