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| Nomenclature |
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Symbol:
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Tg(MT1A-Dyrk1a)Xest
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Name:
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transgene insertion, Xavier Estivill
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MGI ID: |
MGI:3814576 |
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Synonyms: |
TgDyrk1A |
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Transgene:
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Tg(MT1A-Dyrk1a)Xest
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x SJL
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The sheep promoter was used to drive expression of the full-length rat gene in the brain, heart and liver. Four lines were created (lines 9, 28, 31 and 33) that carry 2 to 20 copies of the transgene (2, 2, 20 and 5 copies, respectively). (J:71821)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:140647
Ortiz-Abalia J et al.,
"Targeting Dyrk1A with AAVshRNA attenuates motor alterations in TgDyrk1A, a mouse model of Down syndrome."
Am J Hum Genet 2008 Oct;83(4):479-88
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All: |
4 reference(s)
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Analysis Tools
