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| Nomenclature |
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Symbol:
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Tg(DBH-PTS)6Csic
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Name:
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transgene insertion 6, Chiho Sumi-Ichinose
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MGI ID: |
MGI:3813870 |
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Synonyms: |
DPS, DPS-Pts |
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Transgene:
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Tg(DBH-PTS)6Csic
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, gene disruption) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a 5.8 kb fragment containing the 5' promoter region of the human DBH gene, a rabbit beta-globin intron, a Kozak sequence, and a 441 bp cDNA encoding the human PTS gene. Five independent lines were generated. Line 6 was selected for further study. This line carries about 400 copies of the transgene. High levels of PTS activity are detected in the adrenal glands and olfactory bulbs while lower levels are found in other brain regions and the liver. (J:102278)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:102278
Sumi-Ichinose C et al.,
"Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities."
J Neurochem 2005 Nov;95(3):703-14
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All: |
3 reference(s)
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Analysis Tools
