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| Nomenclature |
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Symbol:
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Tg(SV40-Igh-64C8)H3Hon
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Name:
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transgene insertion H3, Tasuku Honjo
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MGI ID: |
MGI:3813628 |
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Synonyms: |
H3 |
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Transgene:
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Tg(SV40-Igh-64C8)H3Hon
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene consists of a 1.3 kb fragment containing promoter and initiation sequence from SV40, a 0.4 kb cDNA fragment encoding the immunoglobulin heavy chain from the 4C8 hybridoma, a 1.8 kb fragment containing Igh-J3 and Igh-J4 and enhancer sequences, and a 12 kb fragment containing the major intron and Igh-6 from the genomic clones Ch-M-Ig-mu-18 and lambda gtWES-IgH714, respectively. The 4C8 hybridoma contains immunoglobulin genes that encode an anti-murine erythrocyte autoantibody. Seven lines were generated, this a representative record for all lines. The H3 line carries about 10 copies of the transgene on an autosome. RNase protection analysis confirmed expression of the transgene in lymphoid tissues. (J:139864)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:139864
Okamoto M et al.,
"A transgenic model of autoimmune hemolytic anemia."
J Exp Med 1992 Jan 1;175(1):71-9
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All: |
2 reference(s)
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Analysis Tools
