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| Nomenclature |
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Symbol:
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Itm2btm1.1Ldad
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Name:
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integral membrane protein 2B;
targeted mutation 1.1, Luciano D'Adamio
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MGI ID: |
MGI:3810987 |
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Synonyms: |
Bri2- |
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Gene:
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Itm2b
Location:
Chr14:73362231-73385271 bp, - strand
Genetic Position: Chr14,
38.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:138796
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A loxP site was inserted 200 bp 5' of exon 2 and a floxed PGK-neo cassette was inserted in intron 2 via homologous recombination. The floxed PGK-neo cassette and exon 2 were deleted via in vivo Cre-mediated recombination. Western blot analysis of brain membranes from homozygous mice confirmed the absence of protein expression. (J:138796)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Itm2b Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:138796
Matsuda S et al.,
"BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate."
J Neurosci 2008 Aug 27;28(35):8668-76
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All: |
3 reference(s)
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Analysis Tools
