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| Nomenclature |
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Symbol:
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Tg(RCAN1)M9Mapr
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Name:
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Transgene insertion M9, Melanie A Pritchard
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MGI ID: |
MGI:3809545 |
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Synonyms: |
DSCR1-TG, RCAN1ox, Tg(RCAN1)1Mapr |
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Transgene:
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Tg(RCAN1)M9Mapr
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A modified human RCAN1 cDNA containing 4kb of upstream sequence, exon 1, exons 5-7, and the 3'-UTR was constructed. Five transgenic founders were produced. Transgenic mice express about 4 times as much protein as wild-type controls. Results reported are primarily for line M9 although M1 is reported to give similar results. (J:132495)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:132495
Keating DJ et al.,
"DSCR1/RCAN1 regulates vesicle exocytosis and fusion pore kinetics: implications for Down syndrome and Alzheimer's disease."
Hum Mol Genet 2008 Apr 1;17(7):1020-30
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All: |
5 reference(s)
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Analysis Tools
