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| Nomenclature |
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Symbol:
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Tg(Gfap-GFAP*R239H)60TMIke
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Name:
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transgene insertion 60TM, Kazuhiro Ikenaka
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MGI ID: |
MGI:3809243 |
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Synonyms: |
60TM |
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Transgene:
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Tg(Gfap-GFAP*R239H)60TMIke
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The original construct for this transgene consisted of a 2.5 kb fragment of the mouse Gfap promoter followed by a floxed eGFP cDNA, and a human GFAP alpha isophorm cDNA with the R239H mutation. Line A60 containing more than 10 copies of the construct was repeatedly crossed to a cre deleter strain to remove all of the copies of eGFP. The resulting line (60TM) lacks eGFP but retains an estimated 3 copies of the human GFAP cDNA. Each copy of the human GFAP is preceded by a loxP site allowing for Cre-mediated deletion of all but 1 copy of the human GFAP cDNA. (J:139349)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:139349
Tanaka KF et al.,
"Murine model of Alexander disease: analysis of GFAP aggregate formation and its pathological significance."
Glia 2007 Apr 15;55(6):617-31
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All: |
3 reference(s)
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Analysis Tools
