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| Nomenclature |
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Symbol:
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Irs1tm1Mfw
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Name:
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insulin receptor substrate 1;
targeted mutation 1, Morris F White
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MGI ID: |
MGI:3803962 |
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Synonyms: |
Irs1L |
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Gene:
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Irs1
Location:
Chr1:82233101-82291416 bp, - strand
Genetic Position: Chr1,
42.0 cM, cytoband C5
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:137845
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of the 5' untranslated region and a floxed neo cassette was inserted downstream of the open reading frame. Transient cre expression in ES cells was used to remove the neo cassette. (J:137845)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Irs1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:137845
Dong XC et al.,
"Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation."
Cell Metab 2008 Jul;8(1):65-76
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All: |
5 reference(s)
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Analysis Tools
