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| Nomenclature |
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Symbol:
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Hras1tm2Xbr
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Name:
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Harvey rat sarcoma virus oncogene 1;
targeted mutation 2, Xose R Bustelo
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MGI ID: |
MGI:3803587 |
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Synonyms: |
H-RasG12V |
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Gene:
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Hras1
Location:
Chr7:141189105-141194005 bp, - strand
Genetic Position: Chr7,
86.48 cM
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Virgin Hras1tm2Xbr/Hras1tm2Xbr females display mammary gland hyperplasia
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:137729
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: In ES cells containing Hras1tm1Xbr, a floxed hygro STOP cassette was inserted upstream of coding exon 1. In addition, a G to T substitutions was created at the second base of codon 12 of exon 1. This results in an amino acid substitution of valine for glycine. Germ line, cre-mediated recombination was used to remove the hygro STOP cassette. The final alleled contains the G12V mutation and the IRES-beta-geo cassette. (J:137729)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:137729
Schuhmacher AJ et al.,
"A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition."
J Clin Invest 2008 Jun;118(6):2169-79
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All: |
3 reference(s)
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Analysis Tools
