|
|
| Nomenclature |
|
Symbol:
|
Droshatm1Litt
|
|
Name:
|
drosha, ribonuclease type III;
targeted mutation 1, Dan R Littman
|
|
MGI ID: |
MGI:3801076 |
|
Synonyms: |
DroshaF, DroshaflEx9, Droshalox |
|
Gene:
|
Drosha
Location:
Chr15:12824863-12935243 bp, + strand
Genetic Position: Chr15,
5.99 cM
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:138683
|
|
Parent Cell Line:
| E14 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A targeting vector was used to introduce a loxP-flanked neomycin resistance cassette to intron 8, and an additional loxP site to intron 9 of the gene. The construct was electroporated into 129P2/OlaHsd-derived E14 embryonic stem (ES) cells. The neomycin cassette was excised with a C57BL/6 background EIIa-Cre, leaving loxP sites on either side of exon 9. (J:138683)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
| References |
|
Original: |
J:138683
Chong MM et al.,
"The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease."
J Exp Med 2008 Sep 1;205(9):2005-17
|
|
All: |
8 reference(s)
|
|
Analysis Tools
