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| Nomenclature |
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Symbol:
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Lrp2m267Asp
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Name:
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low density lipoprotein receptor-related protein 2;
mutation 267, Andrew S Peterson
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MGI ID: |
MGI:3799273 |
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Synonyms: |
megalinline267 |
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Gene:
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Lrp2
Location:
Chr2:69424340-69586065 bp, - strand
Genetic Position: Chr2,
40.74 cM
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: ENU mutagenesis induced a nucleotide transversion that resulted in an amino acid substitution of a stop codon for tyrosine at position 2721 in the complement repeats domain. This mutation results in the exclusion of the transmembrane domain. (J:136795)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lrp2 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:136795
Zarbalis K et al.,
"A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development."
PLoS Biol 2004 Aug;2(8):E219
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All: |
2 reference(s)
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Analysis Tools
