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| Nomenclature |
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Symbol:
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Tg(FXN)YG8Pook
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Name:
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transgene insertion YG8, Mark A Pook
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MGI ID: |
MGI:3797739 |
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Synonyms: |
YG8 |
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Transgene:
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Tg(FXN)YG8Pook
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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CBA x C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct consists of a 370kb YAC insert that includes the entire human FXN gene with GAA triplet repeat sequences, and was injected into fertilized CBA X C57BL/6 hybrid fertilized oocytes. Founder line YG8 was established, carrying 2 tandem copies of the human FXN gene with two GAA trinucleotide repeat sequences of 82 and 190 repeats. This line displayed a transmission rate of 52% to offspring. (J:91581)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Line YG22 exhibits slightly greater age-related repeat instability, with a bias toward repeat expansion.
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| References |
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Original: |
J:91581
Al-Mahdawi S et al.,
"GAA repeat instability in Friedreich ataxia YAC transgenic mice."
Genomics 2004 Aug;84(2):301-10
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All: |
6 reference(s)
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Analysis Tools
