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| Nomenclature |
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Symbol:
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Fzd5tm2Nat
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Name:
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frizzled homolog 5 (Drosophila);
targeted mutation 2, Jeremy Nathans
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MGI ID: |
MGI:3796577 |
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Synonyms: |
Fz5CKO-AP |
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Gene:
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Fzd5
Location:
Chr1:64730560-64737750 bp, - strand
Genetic Position: Chr1,
32.74 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:136390
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted downstream of exon 1 and a cassette containg a 5' loxP site, alkaline phosphatase gene and an frt-flanked neo gene was inserted downstream of exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette leaving exon 2 floxed and the alkaline phosphatase gene intact. This is a floxed allele and a reporter allele. (J:136390)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:136390
Liu C et al.,
"An essential role for Frizzled5 in neuronal survival in the parafascicular nucleus of the thalamus."
J Neurosci 2008 May 28;28(22):5641-53
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All: |
3 reference(s)
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Analysis Tools
