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| Nomenclature |
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Symbol:
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Cebpatm8.1Nerl
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Name:
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CCAAT/enhancer binding protein (C/EBP), alpha;
targeted mutation 8.1, Claus Nerlov
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MGI ID: |
MGI:3796230 |
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Synonyms: |
CbpaL, CebpaLp30 |
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Gene:
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Cebpa
Location:
Chr7:35119293-35121926 bp, + strand
Genetic Position: Chr7,
21.02 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:136134
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Germ line, cre-mediated recombination was used to remove the neo cassette and results in a missense mutation that produces a STOP codon upstream of the coding region of p42. The absence of p42 and presence of p30 protein products was confirmed by western blot analysis of liver extracts. (J:136134)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cebpa Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:136134
Kirstetter P et al.,
"Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells."
Cancer Cell 2008 Apr;13(4):299-310
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All: |
3 reference(s)
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Analysis Tools
