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| Nomenclature |
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Symbol:
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Pdpk1tm1Dral
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Name:
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3-phosphoinositide dependent protein kinase 1;
targeted mutation 1, Dario R Alessi
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MGI ID: |
MGI:3795190 |
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Synonyms: |
PDK1K465E |
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Gene:
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Pdpk1
Location:
Chr17:24073680-24150924 bp, - strand
Genetic Position: Chr17,
12.23 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:136089
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Exon 12 wass replaced with a floxed neo cassette and an exon 12 containing a nucleotide substitution that results in the amino acid substitution of glutamic acid for lysine at position 465 (K465E). The neo cassette was removed by germ line, cre-mediated recombination. (J:136089)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:136089
Bayascas JR et al.,
"Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance."
Mol Cell Biol 2008 May;28(10):3258-72
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All: |
4 reference(s)
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Analysis Tools
