|
|
| Nomenclature |
|
Symbol:
|
Wt1tm1Mlh
|
|
Name:
|
Wilms tumor 1 homolog;
targeted mutation 1, Martin L Hooper
|
|
MGI ID: |
MGI:3794650 |
|
Synonyms: |
Wt1tmT396 |
|
Gene:
|
Wt1
Location:
Chr2:105126529-105173616 bp, + strand
Genetic Position: Chr2,
55.06 cM, cytoband E
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:135449
|
|
Parent Cell Line:
| HM-1 (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd-Hprtb-m3
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (knock-in) |
|
Mutations: | |
Insertion, Nucleotide substitutions |
| |
|
Mutation details: Exon 9 was replaced with one that contains an inserted Leu2/neo cassette that causes an amino acid substitution of arginine for serine at position 395 and premature termination within the zinc finger 3 domain by inclusion of a translation stop codon at position 396. (J:135449)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Wt1 Mutation:
|
7 strains or lines available |
|
| References |
|
Original: |
J:135449
Patek CE et al.,
"Effects on kidney disease, fertility and development in mice inheriting a protein-truncating Denys-Drash syndrome allele (Wt1 (tmT396))."
Transgenic Res 2008 Jun;17(3):459-75
|
|
All: |
1 reference(s)
|
|
Analysis Tools
