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| Nomenclature |
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Symbol:
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Tg(Myl1-Igf1)1Nros
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Name:
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transgene insertion 1, Nadia Rosenthal
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MGI ID: |
MGI:3793794 |
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Synonyms: |
mIGF-1, MLC/mIgf-1 |
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Transgene:
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Tg(Myl1-Igf1)1Nros
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene construct consists of a rat mIgf-1 cDNA driven by skeletal muscle-specific regulatory elements from the rat myosin light chain (MLC)-1/3 locus. Expression of the MLC/mIgf-1 transgene in adult mice was restricted to skeletal muscle and predominated in muscles enriched in fast fibers, such as the triceps or gastrocnemius. Transgene expression was reduced in slow muscles such as the soleus, where the MLC regulatory cassette is characteristically expressed at very low levels. (J:96432)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:96432
Musaro A et al.,
"Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle."
Nat Genet 2001 Feb;27(2):195-200
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All: |
13 reference(s)
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Analysis Tools
