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| Nomenclature |
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Symbol:
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Tg(Myh6*)140Lnwd
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Name:
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transgene insertion 140, Leslie Leinwand
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MGI ID: |
MGI:3793715 |
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Synonyms: |
HCM |
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Transgene:
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Tg(Myh6*)140Lnwd
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(CBA x C57BL/6)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A rat myosin heavy chain promoter drives the expression of a rat cardiac alpha myosin heavy chain (Myh6) cDNA that was modified by mutating residue 1445 from a G to an A, and the deletion of codons 468-527. This resulted in a R403G substitution and a deletion in the putative actin binding domain in the encoded protein. This transgenic line exhibits a strong phenotype. (J:36522)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:36522
Vikstrom KL et al.,
"Mice expressing mutant myosin heavy chains are a model for familial hypertrophic cardiomyopathy."
Mol Med 1996 Sep;2(5):556-67
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All: |
14 reference(s)
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Analysis Tools
