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| Nomenclature |
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Symbol:
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Csnk1etm1Asil
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Name:
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casein kinase 1, epsilon;
targeted mutation 1, Andrew S I Loudon
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MGI ID: |
MGI:3793318 |
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Synonyms: |
CK1epsilontau |
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Gene:
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Csnk1e
Location:
Chr15:79417856-79443919 bp, - strand
Genetic Position: Chr15,
37.71 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:135186
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Single point mutation |
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Mutation details: A floxed neo cassette was inserted downstream of a modified exon 4 containing a C to T transition at base pair 12555 (C12555T) and an additional loxP site was inserted upstream of the modified exon 4. The neo cassette was removed by germ line, cre-mediated recombination that left the modified exon 4 floxed. The transition mimics a gain of function mutation identified in hamsters as having a destabilizing effect on Per1. (J:135186)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:135186
Meng QJ et al.,
"Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins."
Neuron 2008 Apr 10;58(1):78-88
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All: |
5 reference(s)
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Analysis Tools
