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| Nomenclature |
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Symbol:
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Ror2tm1Anec
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Name:
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receptor tyrosine kinase-like orphan receptor 2;
targeted mutation 1, Aris N Economides
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MGI ID: |
MGI:3793279 |
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Synonyms: |
Ror2W749FLAG, Ror2W749X |
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Gene:
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Ror2
Location:
Chr13:53109312-53286124 bp, - strand
Genetic Position: Chr13,
27.68 cM, cytoband B3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134490
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Parent Cell Line:
| CJ7 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The region encoding W749 to D930 was replaced with a fused, in-frame FLAG-encoding sequence followed by a neo cassette. RT-PCR confirmed the absence of wild-type transcript and the presence of the tagged truncated product in E15.5 embryos. (J:134490)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ror2 Mutation:
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73 strains or lines available |
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| References |
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Original: |
J:134490
Raz R et al.,
"The mutation ROR2W749X, linked to human BDB, is a recessive mutation in the mouse, causing brachydactyly, mediating patterning of joints and modeling recessive Robinow syndrome."
Development 2008 May;135(9):1713-23
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All: |
3 reference(s)
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Analysis Tools
