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| Nomenclature |
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Symbol:
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Klrk1tm1Dhr
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Name:
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killer cell lectin-like receptor subfamily K, member 1;
targeted mutation 1, David H Raulet
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MGI ID: |
MGI:3790957 |
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Synonyms: |
NK2GD- |
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Gene:
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Klrk1
Location:
Chr6:129610323-129623864 bp, - strand
Genetic Position: Chr6,
63.44 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134509
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1b through exon 6 were replaced by a floxed neomycin resistance cassette through homologous recombination. Mice carrying germline mutations were crossed with a cre transgenic mouse strain to remove the neomycin selection cassette, leaving a single loxP site behind. Gene inactivation was confirmed by a lack of protein staining on NK cells using flow cytometry. (J:134509)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Klrk1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:134509
Guerra N et al.,
"NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy."
Immunity 2008 Apr;28(4):571-80
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All: |
7 reference(s)
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Analysis Tools
