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| Nomenclature |
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Symbol:
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Hbbtm2(HBG1,HBB*)Tow
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Name:
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hemoglobin beta chain complex;
targeted mutation 2, Timothy Townes
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MGI ID: |
MGI:3790753 |
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Synonyms: |
-1400-gamma-betaS, Hbbhbetas, Hbbtm2(HBB*)Tow |
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Gene:
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Hbb
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:134980
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: The major and minor beta chains were replaced with a construct made of a 5.66 kb fragment of the human gamma chain including 1400 bp of 5' flanking sequence and a 4.1 kb fragment of the sickle cell form of human HBB in ES cells already containing a replacement of Hba complex with human HBA, Hbatm1(HBA)Tow. Cre-mediated recombination removed the floxed hygro cassette. (J:44160, J:134980)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:134980
Wu LC et al.,
"Correction of sickle cell disease by homologous recombination in embryonic stem cells."
Blood 2006 Aug 15;108(4):1183-8
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All: |
10 reference(s)
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Analysis Tools
